Human Rad51L1 (RAD51B) activation kit by CRISPRa

CAT#: GA104003

RAD51B CRISPRa kit - CRISPR gene activation of human RAD51 paralog B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAD51B
• Locus ID: 5890
• Kit Components:

  GA104003G1, Rad51L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104003G2, Rad51L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104003G3, Rad51L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002877, NM_133509, NM_133510, NM_001321809, NM_001321810, NM_001321812, NM_001321814, NM_001321815, NM_001321817, NM_001321818, NM_001321819, NM_001321821
• Synonyms: R51H2; RAD51L1; REC2
• Summary: 'The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]'