Human RHCE activation kit by CRISPRa

CAT#: GA104100

RHCE CRISPRa kit - CRISPR gene activation of human Rh blood group CcEe antigens

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RHCE
• Locus ID: 6006
• Kit Components:

  GA104100G1, RHCE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104100G2, RHCE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104100G3, RHCE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020485, NM_138616, NM_138617, NM_138618, NM_001330430
• Synonyms: CD240CE; RH; Rh4; RH30A; RHC; RHE; RhIVb(J); RHIXB; RHPI; RhVI; RhVIII
• Summary: 'The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Aug 2016]'