Human ABCE1 activation kit by CRISPRa

CAT#: GA104125

ABCE1 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily E member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ABCE1
• Locus ID: 6059
• Kit Components:

  GA104125G1, ABCE1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104125G2, ABCE1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104125G3, ABCE1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040876, NM_002940
• Synonyms: ABC38; OABP; RLI; RNASEL1; RNASELI; RNS4I
• Summary: 'The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]'