Human Retinoid X Receptor gamma (RXRG) activation kit by CRISPRa

CAT#: GA104241

RXRG CRISPRa kit - CRISPR gene activation of human retinoid X receptor gamma

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RXRG
• Locus ID: 6258
• Kit Components:

  GA104241G1, RXRG gRNA vector 1 in pCas-Guide-CRISPRa

  GA104241G2, RXRG gRNA vector 2 in pCas-Guide-CRISPRa

  GA104241G3, RXRG gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001009598, NM_001256570, NM_001256571, NM_006917, NR_033824
• Synonyms: NR2B3; RXRC
• Summary: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]