Human SCN7A activation kit by CRISPRa

CAT#: GA104298

SCN7A CRISPRa kit - CRISPR gene activation of human sodium voltage-gated channel alpha subunit 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCN7A
• Locus ID: 6332
• Kit Components:

  GA104298G1, SCN7A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104298G2, SCN7A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104298G3, SCN7A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002976, NR_045628
• Synonyms: NaG; Nav2.1; Nav2.2; SCN6A
• Summary: 'This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]'