Human SDHA activation kit by CRISPRa

CAT#: GA104344

SDHA CRISPRa kit - CRISPR gene activation of human succinate dehydrogenase complex flavoprotein subunit A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SDHA
• Locus ID: 6389
• Kit Components:

  GA104344G1, SDHA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104344G2, SDHA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104344G3, SDHA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001294332, NM_004168, NM_001330758
• Synonyms: CMD1GG; FP; PGL5; SDH1; SDH2; SDHF
• Summary: 'This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]'