Human SGSH activation kit by CRISPRa

CAT#: GA104389

SGSH CRISPRa kit - CRISPR gene activation of human N-sulfoglucosamine sulfohydrolase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SGSH
• Locus ID: 6448
• Kit Components:

  GA104389G1, SGSH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104389G2, SGSH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104389G3, SGSH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000199, NM_001352921, NM_001352922, NR_148201
• Synonyms: HSS; MPS3A; SFMD
• Summary: 'This gene encodes the enzyme sulfamidase; one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with the lysosomal storage disease mucopolysaccaridosis IIIA, also known as Sanfilippo syndrome A, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined. [provided by RefSeq, Jun 2017]'