Human SIM1 activation kit by CRISPRa

CAT#: GA104418

SIM1 CRISPRa kit - CRISPR gene activation of human SIM bHLH transcription factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SIM1
• Locus ID: 6492
• Kit Components:

  GA104418G1, SIM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104418G2, SIM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104418G3, SIM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005068
• Synonyms: bHLHe14
• Summary: 'SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]'