Human Solute carrier family 22 member 5 (SLC22A5) activation kit by CRISPRa

CAT#: GA104502

SLC22A5 CRISPRa kit - CRISPR gene activation of human solute carrier family 22 member 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC22A5
• Locus ID: 6584
• Kit Components:

  GA104502G1, Solute carrier family 22 member 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104502G2, Solute carrier family 22 member 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104502G3, Solute carrier family 22 member 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003060, NM_001308122
• Synonyms: CDSP; OCTN2
• Summary: 'Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]'