Human SPI1 activation kit by CRISPRa

CAT#: GA104588

SPI1 CRISPRa kit - CRISPR gene activation of human Spi-1 proto-oncogene

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPI1
• Locus ID: 6688
• Kit Components:

  GA104588G1, SPI1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA104588G2, SPI1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA104588G3, SPI1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001080547, NM_003120
• Synonyms: OF; PU.1; SFPI1; SPI-1; SPI-A
• Summary: This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]