Human STAT4 activation kit by CRISPRa

CAT#: GA104662

STAT4 CRISPRa kit - CRISPR gene activation of human signal transducer and activator of transcription 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STAT4
• Locus ID: 6775
• Kit Components:

  GA104662G1, STAT4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104662G2, STAT4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104662G3, STAT4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243835, NM_003151
• Synonyms: SLEB11
• Summary: 'The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]'