Human LOK (STK10) activation kit by CRISPRa

CAT#: GA104678

STK10 CRISPRa kit - CRISPR gene activation of human serine/threonine kinase 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STK10
• Locus ID: 6793
• Kit Components:

  GA104678G1, STK10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA104678G2, STK10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA104678G3, STK10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005990
• Synonyms: LOK; PRO2729
• Summary: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]