Human T activation kit by CRISPRa

CAT#: GA104722

TBXT CRISPRa kit - CRISPR gene activation of human T-box transcription factor T

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TBXT
• Locus ID: 6862
• Kit Components:

  GA104722G1, T gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104722G2, T gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104722G3, T gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270484, NM_003181, NM_001366285, NM_001366286
• Synonyms: SAVA; TFT
• Summary: 'The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Variation in this gene was associated with susceptibility to neural tube defects and chordoma. A mutation in this gene was found in a family with sacral agenesis with vertebral anomalies. [provided by RefSeq, Sep 2018]'