Human ADA2a (TADA2A) activation kit by CRISPRa

CAT#: GA104730

TADA2A CRISPRa kit - CRISPR gene activation of human transcriptional adaptor 2A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TADA2A
• Locus ID: 6871
• Kit Components:

  GA104730G1, ADA2a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104730G2, ADA2a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104730G3, ADA2a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166105, NM_001291918, NM_001488, NM_133439
• Synonyms: ADA2; ADA2A; hADA2; KL04P; TADA2L
• Summary: 'Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]'