Human TAZ activation kit by CRISPRa

CAT#: GA104757

TAZ CRISPRa kit - CRISPR gene activation of human tafazzin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TAZ
• Locus ID: 6901
• Kit Components:

  GA104757G1, TAZ gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104757G2, TAZ gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104757G3, TAZ gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000116, NM_001303465, NM_181311, NM_181312, NM_181313, NM_181314, NR_024048
• Synonyms: BTHS; CMD3A; EFE; EFE2; G4.5; LVNCX; Taz1
• Summary: 'This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. [provided by RefSeq, Jul 2008]'