Human Thyroxine Binding Globulin (SERPINA7) activation kit by CRISPRa

CAT#: GA104762

SERPINA7 CRISPRa kit - CRISPR gene activation of human serpin family A member 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SERPINA7
• Locus ID: 6906
• Kit Components:

  GA104762G1, Thyroxine Binding Globulin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104762G2, Thyroxine Binding Globulin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104762G3, Thyroxine Binding Globulin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000354
• Synonyms: TBG
• Summary: 'There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]'