Human Treacher Collins syndrome protein (TCOF1) activation kit by CRISPRa

CAT#: GA104797

TCOF1 CRISPRa kit - CRISPR gene activation of human treacle ribosome biogenesis factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TCOF1
• Locus ID: 6949
• Kit Components:

  GA104797G1, Treacher Collins syndrome protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104797G2, Treacher Collins syndrome protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104797G3, Treacher Collins syndrome protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000356, NM_001008656, NM_001008657, NM_001135243, NM_001135244, NM_001135245, NM_001195141
• Synonyms: MFD1; TCS; TCS1; treacle
• Summary: 'This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]'