Human Tryptophan Hydroxylase (TPH1) activation kit by CRISPRa

CAT#: GA104950

TPH1 CRISPRa kit - CRISPR gene activation of human tryptophan hydroxylase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TPH1
• Locus ID: 7166
• Kit Components:

  GA104950G1, Tryptophan Hydroxylase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104950G2, Tryptophan Hydroxylase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104950G3, Tryptophan Hydroxylase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004179
• Synonyms: TPRH; TRPH
• Summary: 'This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]'