Human TPM4 activation kit by CRISPRa

CAT#: GA104955

TPM4 CRISPRa kit - CRISPR gene activation of human tropomyosin 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TPM4
• Locus ID: 7171
• Kit Components:

  GA104955G1, TPM4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104955G2, TPM4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104955G3, TPM4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145160, NM_003290, NM_001367838, NM_001367836, NM_001367837
• Synonyms: HEL-S-108
• Summary: 'This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]'