Human HIRA activation kit by CRISPRa

CAT#: GA105020

HIRA CRISPRa kit - CRISPR gene activation of human histone cell cycle regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HIRA
• Locus ID: 7290
• Kit Components:

  GA105020G1, HIRA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105020G2, HIRA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105020G3, HIRA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003325
• Synonyms: DGCR1; TUP1; TUPLE1
• Summary: 'This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]'