Human Tyrosinase (TYR) activation kit by CRISPRa

CAT#: GA105029

TYR CRISPRa kit - CRISPR gene activation of human tyrosinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TYR
• Locus ID: 7299
• Kit Components:

  GA105029G1, Tyrosinase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105029G2, Tyrosinase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105029G3, Tyrosinase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000372
• Synonyms: ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
• Summary: 'The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]'