Human VPREB1 activation kit by CRISPRa

CAT#: GA105128

VPREB1 CRISPRa kit - CRISPR gene activation of human V-set pre-B cell surrogate light chain 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VPREB1
• Locus ID: 7441
• Kit Components:

  GA105128G1, VPREB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105128G2, VPREB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105128G3, VPREB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303509, NM_007128
• Synonyms: CD179a; IGI; IGVPB; VPREB
• Summary: 'The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]'