Human VR1 (TRPV1) activation kit by CRISPRa

CAT#: GA105129

TRPV1 CRISPRa kit - CRISPR gene activation of human transient receptor potential cation channel subfamily V member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRPV1
• Locus ID: 7442
• Kit Components:

  GA105129G1, VR1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105129G2, VR1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105129G3, VR1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018727, NM_080704, NM_080705, NM_080706
• Synonyms: VR1
• Summary: 'Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]'