Human Tryptophanyl tRNA synthetase (WARS) activation kit by CRISPRa

CAT#: GA105135

WARS CRISPRa kit - CRISPR gene activation of human tryptophanyl-tRNA synthetase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: WARS1
• Locus ID: 7453
• Kit Components:

  GA105135G1, Tryptophanyl tRNA synthetase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105135G2, Tryptophanyl tRNA synthetase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105135G3, Tryptophanyl tRNA synthetase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004184, NM_173701, NM_213645, NM_213646
• Synonyms: GAMMA-2; IFI53; IFP53
• Summary: 'Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'