Human XRCC1 activation kit by CRISPRa

CAT#: GA105173

XRCC1 CRISPRa kit - CRISPR gene activation of human X-ray repair cross complementing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: XRCC1
• Locus ID: 7515
• Kit Components:

  GA105173G1, XRCC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105173G2, XRCC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105173G3, XRCC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006297
• Synonyms: RCC
• Summary: 'The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]'