Human TUSC3 activation kit by CRISPRa

CAT#: GA105377

TUSC3 CRISPRa kit - CRISPR gene activation of human tumor suppressor candidate 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TUSC3
• Locus ID: 7991
• Kit Components:

  GA105377G1, TUSC3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105377G2, TUSC3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105377G3, TUSC3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006765, NM_178234, NM_001356429
• Synonyms: D8S1992; M33; MRT7; MRT22; N33; OST3A
• Summary: This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]