Human NOR1 (NR4A3) activation kit by CRISPRa

CAT#: GA105382

NR4A3 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 4 group A member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NR4A3
• Locus ID: 8013
• Kit Components:

  GA105382G1, NR4A3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105382G2, NR4A3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105382G3, NR4A3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006981, NM_173198, NM_173199, NM_173200
• Synonyms: CHN; CSMF; MINOR; NOR1; TEC
• Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]