Human KMT2D activation kit by CRISPRa

CAT#: GA105405

KMT2D CRISPRa kit - CRISPR gene activation of human lysine methyltransferase 2D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KMT2D
• Locus ID: 8085
• Kit Components:

  GA105405G1, KMT2D gRNA vector 1 in pCas-Guide-CRISPRa

  GA105405G2, KMT2D gRNA vector 2 in pCas-Guide-CRISPRa

  GA105405G3, KMT2D gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003482
• Synonyms: AAD10; ALR; CAGL114; KABUK1; KMS; MLL2; MLL4; TNRC21
• Summary: The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010]