Human PLA2G10 activation kit by CRISPRa

CAT#: GA105548

PLA2G10 CRISPRa kit - CRISPR gene activation of human phospholipase A2 group X

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLA2G10
• Locus ID: 8399
• Kit Components:

  GA105548G1, PLA2G10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105548G2, PLA2G10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105548G3, PLA2G10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003561, NR_133651
• Synonyms: GXPLA2; GXSPLA2; SPLA2
• Summary: This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]