Human BCAR3 activation kit by CRISPRa

CAT#: GA105558

BCAR3 CRISPRa kit - CRISPR gene activation of human BCAR3 adaptor protein, NSP family member

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCAR3
• Locus ID: 8412
• Kit Components:

  GA105558G1, BCAR3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105558G2, BCAR3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105558G3, BCAR3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001261408, NM_001261409, NM_001261410, NM_001308251, NM_003567
• Synonyms: NSP2; SH2D3B
• Summary: Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]