Human Cullin 4B (CUL4B) activation kit by CRISPRa

CAT#: GA105582

CUL4B CRISPRa kit - CRISPR gene activation of human cullin 4B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CUL4B
• Locus ID: 8450
• Kit Components:

  GA105582G1, CUL4B gRNA vector 1 in pCas-Guide-CRISPRa

  GA105582G2, CUL4B gRNA vector 2 in pCas-Guide-CRISPRa

  GA105582G3, CUL4B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001079872, NM_003588, NM_001330624, NM_001369145
• Synonyms: CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2
• Summary: This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]