Human IKK gamma (IKBKG) activation kit by CRISPRa

CAT#: GA105633

IKBKG CRISPRa kit - CRISPR gene activation of human inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IKBKG
• Locus ID: 8517
• Kit Components:

  GA105633G1, IKBKG gRNA vector 1 in pCas-Guide-CRISPRa

  GA105633G2, IKBKG gRNA vector 2 in pCas-Guide-CRISPRa

  GA105633G3, IKBKG gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001099856, NM_001099857, NM_001145255, NM_001321396, NM_001321397, NM_003639
• Synonyms: AMCBX1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
• Summary: This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]