Human DENN (MADD) activation kit by CRISPRa

CAT#: GA105678

MADD CRISPRa kit - CRISPR gene activation of human MAP kinase activating death domain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MADD
• Locus ID: 8567
• Kit Components:

  GA105678G1, MADD gRNA vector 1 in pCas-Guide-CRISPRa

  GA105678G2, MADD gRNA vector 2 in pCas-Guide-CRISPRa

  GA105678G3, MADD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135943, NM_001135944, NM_003682, NM_130470, NM_130471, NM_130472, NM_130473, NM_130474, NM_130475, NM_130476
• Synonyms: DENN; IG20; RAB3GEP
• Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]