Human MNK1 (MKNK1) activation kit by CRISPRa

CAT#: GA105680

MKNK1 CRISPRa kit - CRISPR gene activation of human MAPK interacting serine/threonine kinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MKNK1
• Locus ID: 8569
• Kit Components:

  GA105680G1, MKNK1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105680G2, MKNK1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105680G3, MKNK1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135553, NM_003684, NM_198973, NR_024174, NR_024176, NR_146512, NR_024175
• Synonyms: MNK1
• Summary: This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]