Human TRADD activation kit by CRISPRa

CAT#: GA105784

TRADD CRISPRa kit - CRISPR gene activation of human TNFRSF1A associated via death domain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRADD
• Locus ID: 8717
• Kit Components:

  GA105784G1, TRADD gRNA vector 1 in pCas-Guide-CRISPRa

  GA105784G2, TRADD gRNA vector 2 in pCas-Guide-CRISPRa

  GA105784G3, TRADD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003789, NM_153425, NM_001323552
• Synonyms: Hs.89862
• Summary: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]