Human DR4 (TNFRSF10A) activation kit by CRISPRa

CAT#: GA105843

TNFRSF10A CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 10a

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFRSF10A
• Locus ID: 8797
• Kit Components:

  GA105843G1, TNFRSF10A gRNA vector 1 in pCas-Guide-CRISPRa

  GA105843G2, TNFRSF10A gRNA vector 2 in pCas-Guide-CRISPRa

  GA105843G3, TNFRSF10A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003844
• Synonyms: APO2; CD261; DR4; TRAILR-1; TRAILR1
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]