Human SQSTM1 activation kit by CRISPRa

CAT#: GA105911

SQSTM1 CRISPRa kit - CRISPR gene activation of human sequestosome 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SQSTM1
• Locus ID: 8878
• Kit Components:

  GA105911G1, SQSTM1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105911G2, SQSTM1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105911G3, SQSTM1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142298, NM_001142299, NM_003900
• Synonyms: A170; OSIL; p60; p62; p62B; PDB3; ZIP3
• Summary: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]