Human NFS1 activation kit by CRISPRa

CAT#: GA106021

NFS1 CRISPRa kit - CRISPR gene activation of human NFS1 cysteine desulfurase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NFS1
• Locus ID: 9054
• Kit Components:

  GA106021G1, NFS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106021G2, NFS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106021G3, NFS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001198989, NM_021100, NM_181679, NR_037570
• Synonyms: HUSSY-08; IscS; NIFS
• Summary: Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]