Human PAPSS1 activation kit by CRISPRa

CAT#: GA106027

PAPSS1 CRISPRa kit - CRISPR gene activation of human 3'-phosphoadenosine 5'-phosphosulfate synthase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PAPSS1
• Locus ID: 9061
• Kit Components:

  GA106027G1, PAPSS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106027G2, PAPSS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106027G3, PAPSS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005443
• Synonyms: ATPSK1; PAPSS; SK1
• Summary: Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005). [supplied by OMIM, Mar 2008]