Human HAND1 activation kit by CRISPRa

CAT#: GA106289

HAND1 CRISPRa kit - CRISPR gene activation of human heart and neural crest derivatives expressed 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HAND1
• Locus ID: 9421
• Kit Components:

  GA106289G1, HAND1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106289G2, HAND1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106289G3, HAND1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004821
• Synonyms: bHLHa27; eHand; Hxt; Thing1
• Summary: The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]