Human DRIP130 (MED23) activation kit by CRISPRa

CAT#: GA106300

MED23 CRISPRa kit - CRISPR gene activation of human mediator complex subunit 23

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MED23
• Locus ID: 9439
• Kit Components:

  GA106300G1, MED23 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106300G2, MED23 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106300G3, MED23 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270521, NM_001270522, NM_004830, NM_015979
• Synonyms: ARC130; CRSP3; CRSP130; CRSP133; DRIP130; MRT18; SUR-2; SUR2
• Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]