Human ARHGEF6 activation kit by CRISPRa

CAT#: GA106318

ARHGEF6 CRISPRa kit - CRISPR gene activation of human Rac/Cdc42 guanine nucleotide exchange factor 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGEF6
• Locus ID: 9459
• Kit Components:

  GA106318G1, ARHGEF6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106318G2, ARHGEF6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106318G3, ARHGEF6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001306177, NM_004840
• Synonyms: alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA
• Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]