Human EI24 activation kit by CRISPRa

CAT#: GA106383

EI24 CRISPRa kit - CRISPR gene activation of human EI24 autophagy associated transmembrane protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EI24
• Locus ID: 9538
• Kit Components:

  GA106383G1, EI24 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106383G2, EI24 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106383G3, EI24 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001007277, NM_001290135, NM_004879, NR_110769, NR_110770, NM_001330419
• Synonyms: EPG4; PIG8; TP53I8
• Summary: This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]