Human VPS26 (VPS26A) activation kit by CRISPRa

CAT#: GA106399

VPS26A CRISPRa kit - CRISPR gene activation of human VPS26, retromer complex component A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VPS26A
• Locus ID: 9559
• Kit Components:

  GA106399G1, VPS26A gRNA vector 1 in pCas-Guide-CRISPRa

  GA106399G2, VPS26A gRNA vector 2 in pCas-Guide-CRISPRa

  GA106399G3, VPS26A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001035260, NM_001318944, NM_001318945, NM_001318946, NM_004896
• Synonyms: HB58; Hbeta58; PEP8A; VPS26
• Summary: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]