Human Macrophage Inflammatory Protein 1 beta (CCL4L2) activation kit by CRISPRa

CAT#: GA106400

CCL4L2 CRISPRa kit - CRISPR gene activation of human C-C motif chemokine ligand 4 like 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CCL4L2
• Locus ID: 9560
• Kit Components:

  GA106400G1, CCL4L2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106400G2, CCL4L2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106400G3, CCL4L2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001001435, NM_001291468, NM_001291469, NM_001291470, NM_001291471, NM_001291472, NM_001291473, NM_001291474, NM_001291475, NR_111970
• Synonyms: AT744.2; CCL4L; LAG-1; LAG1; SCYA4L
• Summary: This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]