Human GABA B Receptor 2 (GABBR2) activation kit by CRISPRa

CAT#: GA106405

GABBR2 CRISPRa kit - CRISPR gene activation of human gamma-aminobutyric acid type B receptor subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GABBR2
• Locus ID: 9568
• Kit Components:

  GA106405G1, GABBR2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106405G2, GABBR2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106405G3, GABBR2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005458
• Synonyms: GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099
• Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence. [provided by RefSeq, Jan 2010]