Human NCOR2 activation kit by CRISPRa

CAT#: GA106436

NCOR2 CRISPRa kit - CRISPR gene activation of human nuclear receptor corepressor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NCOR2
• Locus ID: 9612
• Kit Components:

  GA106436G1, NCOR2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106436G2, NCOR2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106436G3, NCOR2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077261, NM_001206654, NM_006312
• Synonyms: CTG26; N-CoR2; SMAP270; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC; TRAC-1; TRAC1
• Summary: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2011]