Human ROC2 (RNF7) activation kit by CRISPRa

CAT#: GA106438

RNF7 CRISPRa kit - CRISPR gene activation of human ring finger protein 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNF7
• Locus ID: 9616
• Kit Components:

  GA106438G1, RNF7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106438G2, RNF7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106438G3, RNF7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001201370, NM_014245, NM_183063, NM_183237, NR_037702, NR_037703
• Synonyms: CKBBP1; ROC2; SAG
• Summary: The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]