Human EIF4A3 activation kit by CRISPRa

CAT#: GA106578

EIF4A3 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 4A3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EIF4A3
• Locus ID: 9775
• Kit Components:

  GA106578G1, EIF4A3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106578G2, EIF4A3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106578G3, EIF4A3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014740
• Synonyms: DDX48; eIF4AIII; MUK34; NMP265; NUK34; RCPS
• Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]