Human MAML1 activation kit by CRISPRa

CAT#: GA106597

MAML1 CRISPRa kit - CRISPR gene activation of human mastermind like transcriptional coactivator 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAML1
• Locus ID: 9794
• Kit Components:

  GA106597G1, MAML1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106597G2, MAML1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106597G3, MAML1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014757
• Synonyms: Mam-1; Mam1
• Summary: This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]